Using Immune Markers to Individualise Therapy for Patients With Triple Negative Breast Cancer

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

KL Owen, LJ Gearing, DJ Zanker, NK Brockwell, WH Khoo, DL Roden, M Cmero, S Mangiola, MK Hong, AJ Spurling, M McDonald, CL Chan, A Pasam, RJ Lyons, HM Duivenvoorden, A Ryan, LM Butler, JM Mariadason, T Giang Phan, VM Hayes

2020-06-04

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma

NK Brockwell, M Alamgeer, B Kumar, G Rivalland, T John, BS Parker

2020-06-01

Background: Malignant pleural mesothelioma (MPM) is well known as an aggressive disease with poor survival. This has sparked trial..

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

DJ Zanker, AJ Spurling, NK Brockwell, KL Owen, JM Zakhour, T Robinson, HM Duivenvoorden, PJ Hertzog, SR Mullins, RW Wilkinson, BS Parker

2020-01-01

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..

Jak-stat signaling: A double-edged sword of immune regulation and cancer progression

KL Owen, NK Brockwell, BS Parker

2019-12-01

Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost all immune regulatory processes..